The History and Development of Sildenafil

Yes, Viagra may help you keep an erection, even after you ejaculate. But if you have an erection that lasts longer than 4 hours, consult a doctor right away. This could be a medical emergency, and it can cause damage to your penis. Viagra can interact with several other medications.

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In people having difficulty with erections, PDE-5 may work too quickly. Viagra works by blocking PDE-5 from working. This way, blood flow to the penis can occur and not be stopped by PDE-5. This also widens your blood vessels to allow more blood to flow into your penis. If you have more questions about how Viagra works, talk with your doctor or pharmacist. It can also interact with alcohol and certain foods. Before taking Viagra, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, or supplements you use. Sharing this information can help you avoid potential interactions. For a more detailed overview of these interactions and what effects they might cause, see this guide to Viagra interactions. Before taking Viagra, discuss your health history with your doctor. Viagra may not be right for you if you have certain medical conditions or other factors affecting your health. Be sure to talk with your doctor if any of the following apply to you: heart problems, such as a history of heart attack, stroke, or high blood pressure heart surgery within the past 6 months irregular penis shape, such as a curved penis (Peyronie’s disease) blood cell disorders, such as sickle cell anemia or low platelet count previous allergic reaction to Viagra or any of its ingredients Whether you have health insurance or not, cost may be a factor when you’re considering Viagra. What you’ll pay for Viagra may depend on several things, such as your treatment plan and the pharmacy you use. Here are a few things to consider regarding cost: Comparing pharmacies: The price of Viagra may vary depending on which pharmacy you use, so it can help to compare prices across pharmacies to find the lowest cost. Generic form: Viagra is available as the generic drug sildenafil.

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Serious side effects from Viagra can occur, but they aren’t common. If you have serious side effects from Viagra, call your doctor right away. But if you think you’re having a medical emergency, you should call 911 or your local emergency number. Serious side effects of Viagra that have been reported include: priapism (sometimes painful erection that lasts longer than 4 hours) loss of vision in one or both eyes Some people may have an allergic reaction to Viagra. Symptoms of a mild allergic reaction can include: flushing (temporary warmth, redness, or deepening of skin color) A more severe allergic reaction is rare but possible. Generics usually cost less than brand-name drugs. Talk with your doctor if you’d like to know whether sildenafil could be an option for you. Drug coupons: You may be able to find drug coupons on prescription discount websites that can reduce the cost of your medication. These coupons cannot be used with insurance copays or benefits, but the discounted price may be lower than what you would pay through insurance. If you have questions about how to pay for your prescription, talk with your doctor or pharmacist. To learn more about Viagra’s price and how to get it, check out these resources: If you have erectile dysfunction, your doctor may recommend that you take Viagra. Be sure to tell your doctor about any medical conditions you have and any medications you take before starting Viagra. Your doctor can determine if this drug is right for you. Some questions that you may wish to ask your doctor include: Is Viagra safe for me given my medical history? What’s the best dosage of Viagra for me? What should I do if Viagra doesn’t work? How should I manage side effects of Viagra? To learn more about Viagra, see these articles: Side Effects of Viagra: What You Need to Know Viagra vs. Levitra: What You Should Know Will Chewing Up Viagra Make It Work Faster? Comparing Cialis and Viagra: Which One Is Best for You? To get information on different conditions and tips for improving your health, subscribe to any of Healthline’s newsletters.

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However, if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room. Find answers to some commonly asked questions about Viagra. Viagra decreases erectile dysfunction symptoms by helping you get and keep an erection. Erections happen when a protein called cyclic guanosine monophosphate (cGMP) is released, causing more blood to flow into your penis. Then, another protein called phosphodiesterase-type 5 (PDE-5) breaks down cGMP, stopping the erection. You may also want to check out the online communities at Bezzy. It’s a place where people with certain conditions can find support and connect with others. No, Viagra will not cure ED, but it will help manage its symptoms. Viagra helps to decrease symptoms of ED by helping you to get and keep an erection. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Sildenafil, sold under the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. [4][8] It is also sometimes used off-label for the treatment of certain symptoms in secondary Raynaud's phenomenon. [9] It is unclear if it is effective for treating sexual dysfunction in females. [8] It can be taken orally (swallowed by mouth), intravenously (injection into a vein), or through the sublingual route (dissolved under the tongue). [8][10] Onset when taken orally is typically within twenty minutes and lasts for about two hours. Common side effects include headaches, heartburn, and flushed skin. [8] Caution is advised in those with cardiovascular disease. [8] Rare but serious side effects include vision problems, hearing loss, and prolonged erection (priapism) that can lead to damage to the penis. [8] Sildenafil should not be taken by people on nitric oxide donors such as nitroglycerin, as this may result in a serious drop in blood pressure.

Alternative and supportive therapies for erection problems

But your doctor will recommend the dosage of Viagra that’s right for you. Note: Other forms of sildenafil (the active drug in Viagra) comes in other strengths, such as 20 mg. But Viagra only comes in the three strengths listed above. For the best results, you should take Viagra at least 30 minutes before sexual activity. For most people, the best time to take Viagra is about 1 hour before sex. Sildenafil acts by blocking phosphodiesterase 5 (PDE5), an enzyme that promotes breakdown of cGMP, which regulates blood flow in the penis. [8] It requires sexual arousal to work, and does not by itself cause or increase sexual arousal. [8] It also results in dilation of the blood vessels in the lungs. Pfizer originally discovered the medication in 1989 while looking for a treatment for angina. [11] It was approved for medical use in the United States and in the European Union in 1998. [5][8][11][12] In 2023, it was the 151st most commonly prescribed medication in the United States, with more than 3 million prescriptions. [13][14] It is available as a generic medication. [15][16] In the United Kingdom, it is available as a pharmacy medicine.

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But it’s safe to take up to 4 hours in advance, depending on how slowly your body processes the drug. Viagra should only be taken once per day. Taking Viagra more frequently or at higher doses than prescribed increases the risk of severe side effects from the drug. Call your doctor if you think you’ve taken too much Viagra. You can also call 800-222-1222 to reach America’s Poison Centers or use its online resource. The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete sexual intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for males with diabetes mellitus. Tentative evidence suggests that sildenafil may help males who experience antidepressant-induced erectile dysfunction. While sildenafil improves some markers of disease in people with pulmonary arterial hypertension, it does not appear to affect the risk of death or serious side effects.

Side effects of Cenforce 120 mg (Sildenafil Citrate)

Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet. They can also include swelling of your tongue, mouth, or throat, which can cause trouble breathing. Call your doctor right away if you have an allergic reaction to Viagra. But if you think you’re having a medical emergency, call 911 or your local emergency number. The table below outlines the basics of Viagra’s dosage as recommended by the drug’s manufacturer. Sildenafil and other PDE5 inhibitors are used off-label to alleviate vasospasm and treat severe ischemia and ulcers in fingers and toes for people with secondary Raynaud's phenomenon;[9][21] these drugs have moderate efficacy for reducing the frequency and duration of vasospastic episodes. [9] As of 2016,[update] their role more generally in Raynaud's was not clear. Sildenafil has shown some potential for improving exercise performance at high altitudes. However, its overall efficacy is not clear. Sildenafil has been studied for high-altitude pulmonary edema (HAPE), but its use is currently not recommended for that indication.